Paramedics rushed to the scene in the city’s Beverly Crest neighbourhood following reports a man had been found lying unconscious in the pool.
The 21-year-old male was treated at the scene, however pronounced dead soon after.
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Moore, 52, and her three children are thought to have been away at the time of the incident.
It is believed a party had been taking place at the home, when the man, believed to be a staff member fell into the pool and drowned.
Demi Moore bought the home with her former husband Ashton Kutcher.