The M1 southbound is at a standstill through Yatala, after a truck reportedly collided with a car.
It happened in the middle lane near exit 34 shortly before 11.30am.
Emergency services are currently on the scene near the City Road exit.
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Motorists have reported lengthy delays travelling southbound.
The Logan Motorway is also enduring severe delays, with traffic only getting through one lane.
A woman was reportedly trapped in her car when paramedics were called to the scene around 11.30am.
Fire fighters were able to extricate her from the vehicle, before paramedics treated her briefly at the scene.
The woman – believed to be in her 50s – has since been taken to Logan Hospital in a stable condition, though complaining of head and neck pain.