Rockhampton’s Fitzroy River is due to peak at around 9 metres at midday on Thursday.
The flood peak is expected to last at that level into the weekend and comes after former Tropical Cyclone Debbie struck.
Authorities estimate that something in the vicinity of 300 homes and businesses will be filled with floodwaters.
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Currently the Fitzroy is at 8.7 metres.
Rockhampton Airport has been closed and a bus service is now running between there and Gladstone until April 14.
Temporary flood barriers have been erected to protect homes in north Rockhampton.
An evacuation centre will open from 9:00AM on Thursday at the James Lawrence Pavilion, Rockhampton Showgrounds.
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